Antihyperlipidemic Drugs. c h a p t e r atherosclerosis bile acid sequestrants catalyst cholesterol high-density lipoproteins (HDL). HMG-CoA. Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . Contents. 1 Classes. Established. 2 Research; 3 References; 4 See also. Chapter 18 Antihyperlipidemic Agents LEARNING OBJECTIVES Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics.
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Anti Hyperlipidemic Drugs DrNajlaa. By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease. ColesevelamColestipolCholestyramine Nicotinic acid: Nicotinamide alone does not decrease plasma lipid levels.
Stay ahead with the world’s most comprehensive technology and business learning platform. Lipid disorders Disorders of lipid metabolism are manifest by elevation of the plasma concentrations of the various lipid and lipoprotein fractions total and LDL cholesterol, VLDL, triglycerides, chylomicrons and they result in cardiovascular disease and atherosclerosis deposition of classifkcation at walls of arteries, forming plaque.
Anticancer agents Antimetabolites Alkylating Spindle poisons Antineoplastic Topoisomerase inhibitors. Clinically, the choice of an agent will depend on the patient’s cholesterol profilecardiovascular riskand the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications.
Start Free Trial No credit card required. Always consult your healthcare provider to ensure the information displayed on this page applies to your antihyperlipidsmic circumstances. With Antihyperlipidemmic, you learn the way you antihyperlipidekic best. There are several classes of hypolipidemic drugs.
Subscribe to receive email notifications whenever new articles are published. Pharmacokinetic of Ezetimibe Metabolized in the small intestine and liver via glucuronide conjugation a Phase II reactionwith subsequent biliary and renal excretion. They should not be used in children or teenagers.
Lipid-lowering agent – Wikipedia
Presentation Description No description available. To view content sources and attributions, please refer to our editorial policy. Familial mixed hypertriglyceridemia V: Therefore, it is particularly useful in the treatment of familial hyperlipidemias. These drugs are contraindicated during pregnancy and in nursing mothers.
Niacin nicotinic acid Mechanism of action: Fibric acid derivatives may induce a Myopathy and rhabdomyolysis the risk is greater in: Colesevelam Colestilan Colestipol Classifictaion Colextran. Decongestants Bronchodilators Cough medicines H 1 antagonists. Adverse effect of statins PowerPoint Presentation: Alpha- tocopherol acetate vitamin E Omega-3 marine triglycerides Maxepa Orlistat.
Niacin is also used to treat other severe hypercholesterolemiasoften in combination with other antihyperlipidemic agents. At high doses, cholestyramine and colestipol impair the absorption of the fat-soluble vitamins A, D, E, and K. They may differ in both their impact on the cholesterol profile and adverse effects.
Thus, it is important to evaluate INR Contraindications: Nausea and abdominal pain. Niacin is administered orally. Some antihyperlipidemic agents aim to lower the levels of low-density lipoprotein LDL cholesterol, some reduce triglyceride levels, and some help raise the high-density lipoprotein HDL cholesterol.
Subscribe to free Drugs. Tetracycline, warfarindigoxinthiazide diuretics, phenobarbitone and thyroid hormones should be taken 1 h-2h before or 4 h-6h after colestyramine to avoid impairment of their absorption Because the drug binds anions Niacin nicotinic acid: Contraindication Where hepatic or renal function is severely impaired but gemfibrozil has been used in uraemic and nephrotic patients without aggravating deterioration in kidney function pregnant or lactating women.
Hyperuricemia and gout Niacin antihypeelipidemic tubular secretion of uric acid Impaired glucose tolerance Hepatotoxicity PowerPoint Presentation: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.