NO PROLIFERATIVAS. – Glomerulonefritis de cambios mínimos. – Glomerulosclerosis segmentaria y focal. – Glomerulonefritis membranosa. GLOMERULOPATIAS Cinthia Alt. Ramirez 30 noviembre Epidemiología Clasificación etiológica Primarias y Secundarias. Las GN. Clasificación e recursos externos Glomerulopatía ou glomerulite é o termo que define ás diversas doenzas que afectan ao glomérulo renal do nefrón, unha.

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Immunohistochemical staining for CD34, a marker of endothelial cells, showed an increased number of vascular channels within ING glomeruli compared with normal controls.

Si continua navegando, consideramos que acepta su uso. Send the link below via email or IM. The adopted biopsy index comprised four elements: Therefore it would be necessary to evaluate the prognostic factors before the selection of treatment modality. In some of these patients, the EM study provides the key information that can not be otherwise obtained.

Renal biopsy in lupus nephritis-what for, when and how often. Pakistan too, being a developing country, lacks widespread availability of EM facilities. Subscribe to our Newsletter. All children presented with NS.

Diagnostic Pathology

SRJ is a prestige metric based on the idea that not all citations are the same. The mean h urinary protein excretion was 4. Patients’ demographic, clinical and laboratory data, including age, sex, renal functions and h urinary protein were retrieved from case files. Rev Infect Dis ; 12 1: The results demonstrate that the ultrastructural study is both helpful and essential to a correct classification of glomerular diseases underlying NS in children in nearly all cases and whenever feasible this should be used in the pathologic glokerulopatias of renal biopsies.

Stoll ML, Gavalchin J. No family history was available of renal disease in our case and genetic testing could not be done due to non-availability of this facility. Different prognostic subgroups obscured by imprecise histologic clasification. Their model comprises the sum of four indices: Diffuse effacement of podocytes. A review of percutaneous renal biopsies.

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Irreproducibility of the activity and chronicity indices limits their utility in the management of lupus glomerulonephritis. The presence of glomerular macrophages correlated with both glomerular alpha-actin expression and type IV collagen deposition, but did not correlate with renal function or proteinuria. This report examines the ability of these indices and individual morphologic variables to predict doubling of serum creatinine SCr; CRX2. All five patients tested clasifjcacion for antineutrophil cytoplasmic antibodies ANCA.



Bacterial infection-related glomerulonephritis in adults. Interpretation of renal biopsies from patients with systemic lupus erythematosus SLE is complicated by the marked variability of the pathology.

We acknowledge the fact the potential role of EM in establishing a diagnosis of MCD in a pediatric population is not without controversy, especially, in the perspective of developing countries.

It could be argued that children presenting with nephrotic-range proteinuria and a normal appearing renal biopsy on LM could be presumed to have MCD. In our previous analysis of percutaneous native renal biopsies over 14 year period, this lesion closely followed MCD in children as a cause of idiopathic NS INS. Rush PG, et al: The contribution of the ultrastructural study to the investigation of the renal biopsies in childhood NS in a developing country like Pakistan is as pertinent as in the developed countries.

Borramiento difuso de podocitos. Value of electron microscopy in diagnosis of renal disease. Contribution of electron microscopy to the final diagnosis ofrenal biopsies in Egyptian patients. The Will Rogers Phenomenon: Lupus nephritis LN is an important cause of renal morbidity and mortality in older children and teenagers.

However, most previous studies examined small numbers of patients and did not adjust for important confounding factors. Glomerulonephritis in bacterial endocarditis. Morphologic findings observed on light microscopy in renal biopsies in 74 children with idiopathic nephrotic syndrome.

HIV-associated immune complex kidney disease. The contribution was considered helpful in cases, in which, although the diagnosis could have been reached based on the combined LM and IF studies, the EM confirmed the diagnosis, especially by excluding diagnoses based exclusively on EM findings. While glomerular macrophage accumulation correlates with mesangial cell activation alpha-actin expression and collagen deposition, and interstitial macrophage accumulation correlates with interstitial fibroblast activation and collagen deposition, only interstitial macrophages correlate with renal function.


The current study is an important contribution to the field of pediatric nephropathology for several reasons; it is the first study from any developing country and from Pakistan on this subject and the second to the only published study from USA on children presenting with NS.

Practical use of electron microscopy for the diagnosis of glomerular disease. Unexpected renal biopsy findings in a febrile Systemic Lupus Erythematosus patient with worsening renal function and heavy proteinuria. The contribution was considered helpful in cases, in which, although the diagnosis could have been reached based on the combined LM and IF studies, the EM confirmed the diagnosis, especially by excluding diagnoses based exclusively on EM findings.

Histopathological spectrum of childhood nephrotic syndrome in Pakistan. One must concur with the authors that “the greatest value of the new biopsy index will lie in the systematic evaluation of entire series of patients” and not in the identification of individuals at risk of adverse outcomes.

In recent reviews of completely worked-up renal biopsies in patients with nephrotic syndrome NSwe have found that the pattern of glomerular diseases, in both the children and the adults, is more akin to that reported recently in developed parts of the world, rather than the tropical pattern reported in earlier studies from Pakistan.

Clinicopathologic characteristics and steroid response of IgM nephropathy in children presenting with idiopathic nephrotic syndrome.

Prognostic factors in diffuse proliferative lupus nephritis. Nodular glomerulosclerosis and membranoproliferative change. It is apparent from these tables that the morphological patterns of glomerular injury as seen on LM are not synonymous with the final diagnoses, the later can only be reached by a correlative approach combining information from LM, IF and EM study with the clinical, laboratory and serological data.