ANGIOFIBROMA NASOFARINGEO PDF

Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

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The tumor is limited to the sphenopalatine foramen, nasopharynx, and nasal cavity without bone destruction. The color depends on the vascular component and may vary from pale white in less vascular lesions to a pink and wine colored mass in highly vascularized ones.

Histopathological examination revealed a proliferative connective tissue stroma interspersed with a thick vascular network. Exclusively endoscopic removal of juvenile nasopharyngeal angiofibroma: Pathogenisis of Juvenile Nasopharyngeal Fibroma A new concept.

Angiofibroma nasofaríngeo juvenil

This article has been cited by other articles in PMC. Traditionally, the NAJ has been parched by transfacial, transoral or combined craniofacial access. Knowledge regarding these specific issues could contribute for the establishment of potential therapeutic targets in the future.

Conclusion Nasal endoscopy, alone or combined with open techniques, was safe for the resection of angiofibromas at different stages, with low morbidity and high efficacy, as shown by complete tumor removal and low recurrence rates. Ear Nose Throat J. Technique The five patients in this series had treatment by endoscopic nasoangiofibroma being that for such surgery was performed with access through both nostrils, the technique of two surgeons and four hands technique.

Sarcoma Lymphoma Immature teratoma Melanoma. Juvenile nasopharyngeal angiofibroma originates in the sphenopalatine forame, causing epistaxes and nasal obstruction. The second patient, also with a Fisch I tumor, underwent clamping of the external carotid arteries without embolization. Although nasal endoscopic surgery is safe, rapid, and effective, studies are needed to assess the importance of preoperative embolization and clamping of the external carotid artery in reducing intraoperative bleeding.

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A comparative study of surgical approches. Am J Clin Oncol.

Besides, it was observed that with the fibrous component development the bleeding trend decreases 9. Article accepted in April 21, Combined surgery consisting of a craniotomy, degloving, and endoscopic surgery in a patient with a Fisch IVA tumor. They account for only 0.

To retrospectively describe our experience in the diagnosis and treatment of patients with juvenile nasopharyngeal angiofibroma. Check for errors and try again. Angiography, although not essential, is often useful in both defining the feeding vessels as well as in preoperative embolisation.

Despite the advances in the field of anatomopathologic description, there are a few studies concerning the JNA molecular and genetic aspects. At the time of diagnosis, the mass classically involves the pterygopalatine fossa. Moreover, the mean blood loss in these patients was mL.

Surgery difficult to excisepreoperative embolization or antiandrogen therapy Chemotherapy or radiation therapy if advanced or aggressive. Impaired Eustachian tube function, facial deformity, proptosis and changes in visual acuity may be seen.

Angiofibroma nasofaríngeo juvenil – Wikipedia, la enciclopedia libre

Longer duration of surgery is associated with greater changes in body homeostasis due to surgical trauma. The JNA vascular and fibrous components present a synchronic maturation, with regular and progressive change of blood vessels, and suggest that the tumor has a growth limited by the vascularization decreasing 5with possible involution having been already reported 7.

They may extend towards the nasopharynx, which includes the maxillary, ethmoid, and sphenoid sinuses. Journal List Int Arch Otorhinolaryngol v. Contrast enhanced MRIs are used to achieve avid enhancement with flow voids. NICOLAI et al 9 in their series of 15 patients found only one patient with a residual lesion on follow-up of 24 months. Otolaryngology – Head and neck surgery.

Immunohistochemical analysis of steroid hormone receptors in nasopharyngeal angiofibromas. Invasion of the intracranial region may lead to cranial nerve palsy.

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Electron dense granules composed of tightly bound RNA protein complexes Stromal cells are myofibroblasts.

It impinges on adjacent structures and causes pressure erosion of bone. The presence of prominent flow voids lead to a salt and pepper appearance on most sequences and are characteristic 5,6. By using this site, you agree to the Terms of Use and Privacy Policy. Since then, several cases have been reported, all showing that endoscopic resection resulted in lower morbidity during the early stages of disease Classification of Fisch Type I: All patients were male, and all had symptoms of progressive nasal obstruction and recurrent epistaxis.

Article received in August 21, Occurs almost entirely pre-adolescent and adolescent males, perhaps to respond to androgens 2,3,4,5,9. Given the short period of patient follow-up, there were only aangiofibroma relapses in two years.

From a triangular region formed by the foramen ovale, a round and lacerated tumor may reach the middle fossa, migrating to the parasellar region and remaining generally extradual and lateral to the cavernous sinus.

Nasopharyngeal Angiofibroma: Review of the Genetic and Molecular Aspects

The development of minimally invasive techniques has led to the increased use of endoscopic surgery for the treatment of nasopharyngeal angiofibroma 21making it ideal for tumors confined to the nasopharynx, nasal cavity, and sphenoid sinus with minimal extension into the pterygopalatine fossa 10 12 amgiofibroma 15 18 Received Aug 21; Accepted Oct 7.

Methods We analyzed 20 patients with nasopharyngeal angiofibroma who underwent surgery in the otolaryngology service between and Reviewing JNA’s pathogenesis, emphasizing genetic and molecular aspects. Gains and losses were detected in autosomal chromosomes and, more frequently, in sexual chromosomes 16,17,